RISK FACTORS OF PULMONARY TUBERCULOSIS IN CHILDREN (0-14 YEARS): SYSTEMATIC LITERATURE REVIEW
DOI:
https://doi.org/10.17501/24246735.2024.9107Keywords:
children, HIV, malnutrition, pulmonary tuberculosis, risk factors, systematic literature reviewAbstract
Pulmonary tuberculosis poses a major global health challenge, particularly among children. Accurate and early diagnosis is critical for effective treatment, yet diagnosing pulmonary tuberculosis in children is often complicated by their nonspecific clinical symptoms and the difficulties in collecting samples. This study aims to identify the risk factors and comorbidities associated with tuberculosis in children. The research methodology employed is a systematic literature review (SLR), with data gathered by documenting all relevant international journal articles sourced from four databases such as Google Scholar, PubMed, Scopus, and ProQuest. During the review process using the PRISMA Flow Diagram, only 7 of the 152 records were initially identified after applying inclusion and exclusion criteria. Key results reveal that HIV infection greatly increases the risk of tuberculosis in children due to weakened immune systems. Malnutrition is another significant factor, with undernourished children facing a much higher risk of contracting tuberculosis. Breastfeeding practices were also found to influence tuberculosis rates, with improper practices associated with higher incidences. Additionally, a history of contact with tuberculosis patients and lower socioeconomic status were found to increase the likelihood of developing the disease. Vitamin D deficiency was also identified as a potential factor influencing tuberculosis outcomes in children. This study highlights several key risk factors for pediatric pulmonary tuberculosis. Tackling these issues through comprehensive healthcare measures could improve early detection and targeted interventions, so it has better health outcomes for children at risk. The government's policy strategy regarding End TB 2030 is also the basis for what must be done immediately to prevent an increase in pulmonary tuberculosis mortality rates.
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Ayalew, M. L., Yigzaw, W. B., Tigabu, A., & Tarekegn, B. G. (2020). Prevalence, associated risk factors and rifampicin resistance pattern of pulmonary tuberculosis among children at debre markos referral hospital, Northwest, Ethiopia. Infection and Drug Resistance, 13, 3863–3872. https://doi.org/10.2147/IDR.S277222
Aziz, K. K. (2018). The Relationship of Exclusive Breastfeeding with the Incidence of Pulmonary Tuberculosis in Children. Jurnal Info Kesehatan, 16(2), 236–243. https://doi.org/10.31965/infokes.vol16.iss2.224
Azzahrain, A. S., Afifah, A. N., & Yamani, L. N. (2023). Detection of Tuberculosis in Toddlers and its Risk Factor at East Perak Health Center Surabaya. Jurnal Kesehatan Lingkungan, 15(2), 92–98. https://doi.org/10.20473/jkl.v15i2.2023.92-98
Buonsenso, D., Pata, D., Colonna, A. T., Ferrari, V., Salerno, G., & Valentini, P. (2022). Vitamin D and Tuberculosis in Children: A Role in the Prevention or Treatment of the Disease? In Monaldi Archives for Chest Disease (Vol. 92, Issue 2112, pp. 1–7). Page Press Publications. https://doi.org/10.4081/monaldi.2022.2112
Choi, S.-W., Im, J.-J., Yoon, S.-E., Kim, S.-H., Cho, J.-H., Jeong, S.-J., Park, K.-A., & Moon, Y.-S. (2023). Lower socioeconomic status associated with higher tuberculosis rate in South Korea. BMC Pulmonary Medicine, 23(418). https://doi.org/10.1186/s12890-023-02713-z
Cole, B., Nilsen, D. M., Will, L., Etkind, S. C., Burgos, M., & Chorba, T. (2020). Essential Components of a Public Health Tuberculosis Prevention, Control, and Elimination Program: Recommendations of the Advisory Council for the Elimination of Tuberculosis and the National Tuberculosis Controllers Association. MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports, 69(7), 1–27. https://doi.org/10.15585/mmwr.rr6907a1
DeAtley, T., Workman, L., Theron, G., Bélard, S., Prins, M., Bateman, L., Grobusch, M. P., Dheda, K., Nicol, M. P., Sorsdahl, K., Kuo, C., Stein, D. J., Zar, H. J., Kuo, C., Stein, D. J., & Zar, H. J. (2021). The Child Ecosystem and Childhood Pulmonary Tuberculosis: A South African Perspective. Pediatric Pulmonology, 56(7), 1–19. https://doi.org/10.1002/ppul.25369
Dodd, P. J., Prendergast, A. J., Beecroft, C., Kampmann, B., & Seddon, J. A. (2017). The impact of HIV and antiretroviral therapy on TB risk in children: A systematic review and meta-analysis. Thorax, 72, 559–575. https://doi.org/10.1136/thoraxjnl-2016-209421
Fry, S. H., Barnabas, S., & Cotton, M. F. (2019). Tuberculosis and HIV - An update on the “cursed duet” in children. In Frontiers in Pediatrics (Vol. 7, Issue 159, pp. 1–12). Frontiers Media S.A. https://doi.org/10.3389/fped.2019.00159
Khalil, B., Hussain, M., Taj, W., Iqbal, S., Irshad, M., Khan, M. J., & Ullah, I. (2020). Frequency of Pulmonary Tuberculosis in Severely Acute Malnourished Children and Its Association Acute Malnourished Children and Its Association with Inappropriate Feeding Practices with Inappropriate Feeding P. Journal of Medical Sciences, 28(3), 252–255. Retrieved from https://jmedsci.com/index.php/Jmedsci/article/view/799
Maphalle, L. N. F., Michniak-Kohn, B. B., Ogunrombi, M. O., & Adeleke, O. A. (2022). Pediatric Tuberculosis Management: A Global Challenge or Breakthrough? Children, 9(1120), 1–42. https://doi.org/10.3390/children9081120
Nidoi, J., Muttamba, W., Walusimbi, S., Imoko, J. F., Lochoro, P., Ictho, J., Mugenyi, L., Sekibira, R., Turyahabwe, S., Byaruhanga, R., Putoto, G., Villa, S., Raviglione, M. C., & Kirenga, B. (2021). Impact of Socio-economic Factors on Tuberculosis Treatment Outcomes in North-Eastern Uganda: A Mixed Methods Study. BMC Public Health, 21(2167), 1–16. https://doi.org/10.1186/s12889-021-12056-1
Olivier, C., & Luies, L. (2023). WHO Goals and Beyond: Managing HIV/TB Co-infection in South Africa. SN Comprehensive Clinical Medicine, 5(251), 1–13. https://doi.org/10.1007/s42399-023-01568-z
Ramos, S., Gaio, R., Ferreira, F., Leal, J. P., Martins, S., Santos, J. V., Carvalho, I., & Duarte, R. (2017). Tuberculosis in children from diagnosis to decision to treat. Revista Portuguesa de Pneumologia (English Edition), 23(6), 317–322. https://doi.org/10.1016/j.rppnen.2017.06.004
Robinson, H., Calamia, M., Gläscher, J., Bruss, J., & Tranel, D. (2014). Neuroanatomical correlates of executive functions: A neuropsychological approach using the EXAMINER battery. Journal of the International Neuropsychological Society, 20(1), 52–63. https://doi.org/10.1017/S135561771300060X
Tamara, L., Kartasasmita, C. B., Alam, A., & Gurnida, D. A. (2022). Effects of Vitamin D supplementation on resolution of fever and cough in children with pulmonary tuberculosis: A randomized double-blind controlled trial in Indonesia. Journal of Global Health, 12(04013), 1–8. https://doi.org/10.7189/jogh.12.04013
Thomas, T. A. (2017). Tuberculosis in Children. Pediatric Clinics of North America, 64(4), 893–909. https://doi.org/10.1016/j.pcl.2017.03.010
Tolossa, D., Medhin, G., & Legesse, M. (2014). Community knowledge, attitude, and practices towards tuberculosis in Shinile town, Somali regional state, eastern Ethiopia: a cross-sectional study. BMC public health, 14, 804. https://doi.org/10.1186/1471-2458-14-804
Venturini, E., Turkova, A., Chiappini, E., Galli, L., de Martino, M., & Thorne, C. (2014). Tuberculosis and HIV co-infection in children. In BMC Infectious Diseases (Vol. 14, Issue 55, pp. 1–10). BioMed Central Ltd. https://doi.org/10.1186/1471-2334-14-S1-S5
Vonasek, B. J., Rabie, H., Hesseling, A. C., & Garcia-Prats, A. J. (2022). Tuberculosis in Children Living With HIV: Ongoing Progress and Challenges. Journal of the Pediatric Infectious Diseases Society, 11(3), 72–78. https://doi.org/10.1093/jpids/piac060
WHO. (2024). Social Determinants. World Health Organization. http://www.who.int/teams/global-tuberculosis-programme/populations-comorbidities/social-determinants
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Copyright (c) 2025 Machrumnizar Machrumnizar, Adang Bachtiar, Rina Kurniasri Kusumaratna, Nikmatul Hidayah, Ruth Christy Setyaningtyas , Meiyanti Meiyanti
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