Lipid-lowering Effect of Alpha-lipoic acid: A Systematic Review and Meta-analysis of Randomized Controlled Trials

2024-11-11T18:39:36+0530

Alpha-lipoic acid (ALA) has various effects on health, one of which is its impact on lipid levels in the blood. Preclinical studies have demonstrated this effect. Nonetheless, the outcomes of clinical evaluations have been contradictory. Systematic reviews on this subject have also yielded conflicting findings. This study conducted a systematic review and meta-analysis of randomized controlled trials to evaluate the effects of ALA on changes in various blood lipid levels. We discovered that ALA significantly reduced triglyceride (TG) levels (-6.299 mgdL^-1 95% CI -10.104 to -2.494); however, the studies contributing to this significant finding were found to confer a high risk of bias. In contrast, no significant effects were observed on the levels of total cholesterol (TC; 0.304 mgdL^-1 95% CI -3.436 to 4.044), High-density Lipoprotein (HDL; -1.460 mgdL^-1 95% CI -5.445 to 2.525), or Low-density Lipoprotein (LDL; 0.226 mgdL^-1 95% CI -0.711 to 1.163). Although the dose of ALA and the duration of administration did not show statistically significant effects, it was observed that ALA doses not exceeding 1,200 mg per day and administration for approximately 16 weeks were more effective in reducing TG levels. We discovered that our study also contained research with small sample sizes and high degree of heterogeneity between studies. These findings highlight the potential lipid-modifying consequence of ALA, especially triglyceride-lowering effect, emphasizing the prominence of appropriate dosing along with duration of treatment.

CITRUS-DERIVED BIOFLAVONOIDS: AN ALTERNATIVE APPROACH TOWARDS TREATING DIABETES, NEURODEGENERATIVE DISEASES AND CANCER

2025-01-21T09:55:30+0530

Diabetes, neurodegenerative diseases and cancer are some of the major public health issues worldwide. Various synthetic drugs are available for the treatment of these diseases, however, most of them exhibit side-effects. Despite their availability, most of these drugs are unaffordable for a particular sect of population. Also, most of the commercial drugs exhibit critical effects upon long term consumption and sometimes can also be lethal. Flavonoids are bioactive polyphenols that has potent pharmacological properties. In the recent times, apigenin, quercetin and naringenin, derived from citrus plants, are used extensively in the treatment of various diseases and being herbal in nature, these compounds are reported to show no significant side-effects. These said dietary flavonoids do possess high antioxidant, anti-inflammatory, anti-hyperglycemic and anti-apoptotic properties. This review summarises the adverse effects of synthetic drugs available for treatment, suggesting the efficacy of the mentioned flavonoids as possible alternative medicinal approach against the usage of the commercial drugs. In experimental researches like cell culture and animal models, these dietary flavonoids can be used alternatively towards treating those diseases, considering their positive effects. However, further clinical trials are required on humans to check for toxicity.

Proceedings of the International Conference on Food, Nutrition, Health and Lifestyle

Lipid-lowering Effect of Alpha-lipoic acid: A Systematic Review and Meta-analysis of Randomized Controlled Trials

CITRUS-DERIVED BIOFLAVONOIDS: AN ALTERNATIVE APPROACH TOWARDS TREATING DIABETES, NEURODEGENERATIVE DISEASES AND CANCER