THE IN-VIVO POTENTIAL OF AVOCADO JUICE (Persea americana Mill) ON CHOLESTEROL LEVELS
DOI:
https://doi.org/10.17501/3021677X.2023.1117Keywords:
quail egg yolk, hypolipidemic agent, cholesterol levels, avocado juiceAbstract
An increase in blood cholesterol levels is one of the triggers for atherosclerosis. The use of natural components, such as avocado fruit juice, is an alternative to lowering cholesterol levels. Avocados contain hypolipidemic agents such as beta-sitosterol, omega-9, oleic acid, pantothenic acid (vitamin B5), niacin (vitamin B3), vitamins A, C, and E, cysteine amino acid, selenium, and fruit fiber. The study's goal was to examine the potential effects of providing avocado juice on cholesterol levels. The pretest-posttest design with a control group is used in this type of experimental research. The research sample consisted of 36 male white rats aged 2-3 months which were divided into 3 normal, positive, and negative control groups, and 3 treatment groups with avocado juice doses of 3.5mL, 4mL, and 4.5mL. The research phase involved acclimatization and generation of hypercholesterolemic rats by inducing quail egg yolk orally and assessing the effectiveness of avocado juice orally once a day for 7 days. Cholesterol levels were tested three times: after acclimation, induction by oral quail egg yolk, and administration of avocado juice. After egg yolk induction, the average cholesterol level in all treatment groups was 139.1 mgdL-1, 164.5 mgdL-1, and 190.1 mgdL-1, respectively. Following the administration of avocado juice, there was a decrease in all treatment groups with mean cholesterol levels of P1, P2, and P3, or 68.7 mgdL-1, 64.1 mgdL-1, and 42 mgdL-1. These findings are supported by test results from One Way Anova, which showed that after the administration of avocado juice, there were variations in cholesterol levels between groups. The study's finding is that consuming avocado juice can lower cholesterol levels.
Downloads
References
Anggraheny, H. D. (2007). Artikel penelitian pengaruh pemberian jus Persea americana Mill . Artikel Penelitian Universitas Diponegoro Semarang, 1–18.
Bhuyan, D. J., Alsherbiny, M. A., Perera, S., Low, M., Basu, A., Devi, O. A., Barooah, M. S., Li, C. G., & Papoutsis, K. (2019). The odyssey of bioactive compounds in Avocado (Persea Americana) and their health benefits. Antioxidants, 8(10). https://doi.org/10.3390/antiox8100426
Di Stefano, V., Avellone, G., Bongiorno, D., Indelicato, S., Massenti, R., & Lo Bianco, R. (2017). Quantitative evaluation of the phenolic profile in fruits of six avocado (Persea americana) cultivars by ultra-high-performance liquid chromatography-heated electrospray-mass spectrometry. International Journal of Food Properties, 20(6), 1302–1312. https://doi.org/10.1080/10942912.2016.1208225
Elbadrawy, E., & Shelbaya, L. (2013). Journal of American Science 2013;9(12) http://www.jofamericanscience.org Hypolipidemic activities of hydroalcoholic extract of avocado fruit on high cholesterol fed diet in rats and its antioxidant effect. Journal of American Science, 9(12), 337–343.
Fairudz, A., & Nisa, K. (2015). Pengaruh serat pangan terhadap kadar kolesterol penderita overweight. Medical Journal Of Lampung University, 4(8), 121–126.
Figueroa, J. G., & Segura-carretero, A. (2017). Comprehensive identi fi cation of bioactive compounds of avocado peel by liquid chromatography coupled to ultra-high-de fi nition accurate-mass Q- TOF. June.
Ghani, L., Susilawati, M. D., & Novriani, H. (2016). Faktor Risiko Dominan Penyakit Jantung Koroner di Indonesia. Buletin Penelitian Kesehatan. https://doi.org/10.22435/bpk.v44i3.5436.153-164
Giknis, M L A., Clifford, C. B. (2008). Clinical Laboratory Parameters for crl: WI(Han) Rats. Charles River Laboratories, 1–14. https://www.criver.com/sites/default/files/Technical Resources/Clinical Laboratory Parameters for Crl-WI(Han) Rats - March 2008.pdf
Grosso, G., Bei, R., Mistretta, A., Marventano, S., Calabrese, G., Masuelli, L., Giganti, M. G., Modesti, A., Galvano, F., & Gazzolo, D. (2013). Effects of vitamin C on health: A review of evidence. Frontiers in Bioscience, 18(3), 1017–1029. https://doi.org/10.2741/4160
Hanifah, W., Oktavia, W. S., & Nisa, H. (2021). Faktor Gaya Hidup Dan Penyakit Jantung Koroner: Review Sistematik Pada Orang Dewasa Di Indonesia. Penelitian Gizi Dan Makanan (The Journal of Nutrition and Food Research), 44(1), 45–58. https://doi.org/10.22435/pgm.v44i1.4187
Hariadini, A. L., Sidharta, B., Ebtavanny, T. G., & Minanga, E. putri. (2020). Hubungan Tingkat Pengetahuan Dan Ketepatan Penggunaan Obat Simvastatin Pada Pasien Hiperkolesterolemia Di Apotek Kota Malang. Pharmaceutical Journal of Indonesia, 005(02), 91–96. https://doi.org/10.21776/ub.pji.2020.005.02.4
Kaczmarczyk, M. M., Miller, M. J., & Freund, G. G. (2012). The health benefits of dietary fiber: Beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer. Metabolism: Clinical and Experimental, 61(8), 1058–1066. https://doi.org/10.1016/j.metabol.2012.01.017
Mayasari, D. R., & Rahayuni, A. (2014). Pengaruh pemberian serbuk biji labu kuning (Cucurbita moschata) terhadap penurunan kolesterol ldl pada tikus wistar hiperkolesterolemia. Journal of Nutrition College, 3(4), 432–439. https://doi.org/10.14710/jnc.v3i4.6823
Primadi, O. (2017). Penyakit Jantung Penyebab Kematian Tertinggi, Kemenkes Ingatkan Cerdik. In Kementrian Kesehatan Republik Indonesia.
Salazar-lópez, N. J., Domínguez-avila, J. A., Elhadi, M., Belmonte-herrera, B. H., & Wall-medrano, A. (2020). Journal Pre-proofs.
Sargowo, D. (2015). Patogenesis Aterosklerosis. UB Press. https://books.google.co.id/books?hl=en&lr=&id=P_dRDwAAQBAJ&oi=fnd&pg=PA42&dq=aterosklerosis&ots=W8uTj1dlLx&sig=C3N3Y1wgG2Z3ZxTTaXRWJaLX4aE&redir_esc=y#v=onepage&q=aterosklerosis&f=false
Setianingsih, N., Nahdiyah, N., & Purnamasari, R. (2017). alpukat 333.pdf (pp. 48–53). https://doi.org/https://doi.org/10.19109/Biota.v3i2.1256
Simarmata, Y., Manurung, K., Harefa, K., Sri, M., & Hasibuan, R. (2018). Skrining Fitokimia dan Uji Aktivitas Antidiabetes dari Ekstrak Etanol Daging Buah Alpukat (Persea americana Mill.). Farmanesia, 5(1), 2–7.
Sinulingga, B. O. (2020). Pengaruh konsumsi serat dalam menurunkan kadar kolesterol. Jurnal Penelitian Sains, 22(1), 9–15. https://doi.org/10.26554/jps.v22i1.556
Tarmizi, N. S. (2023). Penyakit Jantung Penyebab Utama Kemenkes Perkuat Layanan. Kementerian Kesehatan, 1–5. https://sehatnegeriku.kemkes.go.id/baca/rilis-media/20220929/0541166/penyakit-jantung-penyebab-utama-kematian-kemenkes-perkuat-layanan-primer/
Tremocoldi, M. A., Rosalen, P. L., Franchin, M., Massarioli, A. P., Denny, C., Daiuto, É. R., Paschoal, J. A. R., Melo, P. S., & De Alencar, S. M. (2018). Exploration of avocado by-products as natural sources of bioactive compounds. PLoS ONE, 13(2), 1–12. https://doi.org/10.1371/journal.pone.0192577
Wardani, Y. A. K. (2014). Potential of avocado (Persea americana mill) to reduce coronary heart disease risk. Jurnal Agromed Unila, 1(1), 55–60.
Yani, M. (2015). Mengendalikan Kadar Kolesterol Pada Hiperkolesterolemia. Olahraga Prestasi, 11(2), 3–7. https://doi.org/10.1017/CBO9781107415324.004
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 F Nuroini, E Erliana, JT Isworo
This work is licensed under a Creative Commons Attribution 4.0 International License.
